Projects

A01

Linking DNA damage response and insulin action via the post-translational modification of TSC22D4 in diabetic late complications

Prof. Dr. Stephan Herzig

A02

Diabetic complications as a result of iron-induced reactive oxygen species (independent of methylglyoxal)

Prof. Dr. Martina Muckenthaler

A03

Regulation of Glo1 activity via post-translational modifications and impact on cellular metabolism

Prof. Dr. Aurelio Teleman

A04

The Importance of Enzymatic Regulation of Methylglyoxal Metabolism in Diabetic Neuropathy

Dr. Thomas Fleming

B01

Characterization of reactive metabolite detoxifying enzyme systems in zebrafish under diabetic conditions

Apl. Prof. Dr. Jens Kroll

B02

The role of TRPC cation channels in hypoglycemia associated autonomic failure in experimental diabetes models.

Prof. Dr. Marc Freichel

B03

Epigenetic Regulation of adaptive und maladaptive effects through O-GlcNAc-modifications in diabetic hearts

Prof. Dr. Johannes Backs

B05

Relevance of Endoneural Substrate Deposits and Reactive Metabolites in the Pathogenesis of Diabetic Polyneuropathy: MR-Neurography Studies

Prof. Dr. Sabine Heiland
PD Dr. Daniel Schwarz

B06

Functional roles and mechanisms of ROS-dependent sumoylation in diabetic neuropathy

Prof. Dr. Rohini Kuner
Dr. Nitin Agarwal

B07N

Regulation of mitochondrial quality and function in the context of diabetic nephropathy – Relevance of coagulation proteases

Prof. Dr. Berend Isermann

C03

Glucose and reactive metabolites in the diabetic retina - preventive approaches against Vasoregression

Prof. Dr. Hans-Peter Hammes

C05

Carnosine metabolism dependent protection from reactive metabolite induced diabetic complications

Apl. Prof. Dr. Verena Peters
Apl. Prof. Dr. Claus Peter Schmitt

C06

RAGE mediated DNA repair at the interface between damage by reactive metabolites and repair of diabetic complications

Prof. Dr. Dr. h.c. Peter Paul Nawroth

C07N

Loss of the MG-induced cellular defense mechanism leads to the development of diabetic complications

Dr. Johanna Zemva

KS01

Periodic fasting in patients with type 2 diabetes and albuminuria

Prof. Dr. Stephan Herzig
Prof. Dr. Dr. h.c. Peter Paul Nawroth

S01

Liquid-Chromatography Tandem Mass Spectrometry (LC-MS/MS) Core Facility

Dr. Thomas Fleming
Prof. Dr. Rüdiger Hell

S02

Diabetes-spezifische Biomaterialbank

Dr. Constantin Schwab (seit 07/2020)
Prof. Dr. Esther Herpel (bis 07/2020)

S03N

Platform for CRISPR/Cas9 technology and AAV8 atherosclerosis model

Prof. Dr. Marc Freichel