2nd Heidelberg International Symposium 
on Diabetic Complications 

16. und 17.10.2015

The conference will highlight recent exciting developments in key areas of vascular biology and diabetes, including current progress in vascular-metabolic aspects and clinical perspectives in the treatment of diabetes and its long-term complications. We envision contributions allowing the audience to gain an overview of the recent progress on these fundamental topics in biomedicine.

Invited Speakers

Sven Enerbäck|University of Gothenburg|Gothenburg|Sweden      
Per-Henrik Groop|Helsinki University|Helsinki|Finland      
Katerina Kankova|Masaryk University|Brno|Czech Republic      
George Kunos|National Institutes of Health (NIH) - NIAAA|Rockville|USA      
Eckhard Lammert|Heinrich-Heine-Universität|Dusseldorf|Germany      
Michael Potente|Max Planck Institute for Heart and Lung Research|Bad Nauheim|Germany      
Klaus Preissner|Justus-Liebig-University|Giessen|Germany      
Peter Rossing|Aarhus University/ Steno Diabetes Center A/S|Gentofte|Denmark      
Christiana Ruhrberg|University College London|London|UK      
Alan Stitt|Queen's University Belfast|Belfast|UK      
Paul Thornalley|University of Warwick|Coventry|UK      
Karl Tryggvason|Karolinska Institut & Duke-NUS|Stockholm & Singapore|Sweden & Singapore      
Antonio Vidal-Puig|University of Cambridge|Cambridge|UK      
Kenneth Walsh|Boston University School of Medicine|Boston|US      
Christian Weber|Ludwig-Maximilians-University|Munich|      

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Program - Friday, October 16

08.00 - 08.50|Registration  
08.50|Welcome Stephan Herzig, Helmholtz Zentrum München, Institute for Diabetes and Cancer, Munich  
09.00 - 12.30|Session I: Emerging molecular concepts in diabetic vascular dysfunction  
09.00|Neuropilin signaling in vascular eye pathology Christiana Ruhrberg  
09.30|Innate immune responses and Diabetic Retinopathy Alan Stitt  
10.00|Metabolic regulation of endothelial growth and quiescence Michael Potente  
10.30|Coffee break  
11.00|Diabetic nephropathy susceptibility genes Karl Tryggvason  
11.30|New treatment options in diabetic nephropathy Peter Rossing  
12.00 - 12.30|Poster Talks I  
12.00|Cation channels of the TRPC family contribute to development of nephropathy and retinopathy in the STZ model Dagmar Schumacher  
12.10|Hyperglycemic memory - Mechanisms relevant to the diabetic retina Patrick Friedrichs  
12.20|Anks6(p.R823W)  overexpression in kidney affects retinal degeneration Jihong Lin  
12.30 - 14.30|Lunch break and poster session Posters are displayed in Foyer  
14.30 - 18.00|Session II: Stress signaling pathways in diabetic complications  
14.30|Alarming news and views of extracellular RNA in inflammation and vascular remodeling Klaus T. Preissner  
15.00|Novel antifibrotic treatment strategy using peripheral CB1 receptor inhibitors with secondary targets Georg Kunos  
15.30|Dicarbonyl stress and glyoxalase 1 in the development of vascular complications of diabetes Paul Thornalley  
16.00|Coffee break  
16.30|Glyoxalase system in clinically relevant metabolic stresses in diabetes: hyperglycemia, high glucose variability, lipotoxicity and uremia Katerina Kankova  
17.00|Adipokine links between metabolic and cardiovascular disease Kenneth Walsh  
17.30 - 18.00|Poster Talks II  
17.30|Age-related carbonylation in glomeruli of diabetic mice influences anti-oxidative defense mechanisms Tanja Wiedenmann  
17.40|Microvascular reactivity relates to the skin autofluorescence but not to soluble receptor for advanced glycation endproducts in patients with diabetes Jan Škrha jr.  
17.50|Post-glucose load plasma α-dicarbonyl concentrations are increased in individuals with impaired glucose metabolism and type 2 diabetes: The CODAM study Dionne Maessen  


Program - Saturday, October 17

08.00 - 08.50|Registration  
09.00 - 12.30|Session III: Beyond complications  
09.00|Diabetic nephropathy – genes or the environment? Per-Henrik Groop  
09.30|Brown adipose tissue - of mice and men Sven Enerbäck  
10.00|Adipose tissue expandibility, lipotoxicity and the metabolic syndrome  Antonio Vidal-Puig  
10.30|Coffee break  
11.00|Novel targets for vascular protection Christian Weber  
11.30|NMDA-receptors - novel drug targets for diabetes treatment Eckhard Lammert  
12.00 - 12.30|Poster Talks III  
12.00|Hypoxia plays a key role in the accumulation of carbonyl stress in obese adipose tissue Katrien Gaens  
12.10|The association between dietary intake of advanced glycation endproducts and plasma levels of advanced glycation endproducts: THE CODAM STUDY Jean Scheijen  
12.20|Advanced glycation end-products as long-term retrospective indicators of glycemic balance in children with non-complicated type 1 diabetes mellitus Stéphane Jaisson  
12.30|Concluding remarks Peter Nawroth  
12.40 - 14.30|Lunch break and poster session Posters are displayed in Foyer  
14.30 - 16.00|EASD Study Group Talks  
14.30|Skin AGEs and skin fluorescence in the progression of micro- and macrovascular complications in Type 1 diabetes: The plot thickens Vincent Monnier  
14.50|Methylglyoxal modification of low density lipoprotein – a novel route to the pro-atherogenic, small dense LDL with increased arterial proteoglycan binding and aortal retention Naila Rabbani  
15.10|Over-expression of the AGE receptor (AGE-R1) during high age feeding results in hepatic fibrosis and exacerbates glucose intolerance Josephine Forbes  
15.30|Centrally obese women present low sRAGE but unaltered SSAO/sVAP-1 levels regardless of presence/absence of additional cardiometabolic risk factors Katerina Šebeková  
16.00 - 16.30|Coffee break  
16.30 - 17.30|EASD Business Meeting