3rd Heidelberg International Symposium 
on Diabetic Complications 

6. bis 8.10.2016

The conference will highlight recent exciting developments in key areas of diabetic (long-term) complications, covering a wide range from vascular biology and neuropathology to epigenetics and clinical studies.
We envision contributions allowing the audience to gain an overview of the recent exciting progress on these fundamental topics.

Invited Speakers

Francesco Beguinot|University of Naples|Naples|Naples      
Neil Docherty|University College Dublin|Dublin|Ireland      
Phillipe Froguel|Imperial College London University/ Lille University|London /Lille|UK / France      
Anthony Heagerty|University of Manchester|Manchester|UK      
Stephan Herzig|Helmholtz Zentrum München|Munich|Germany      
Martin Hrabe de Angelis|Helmholtz Zentrum München|Munich/Neuherberg|Germany      
Berend Isermann|University Medical Center Hamburg-Eppendorf|Hamburg|Germany      
Stephan Herzig|Helmholtz Center Munich & Heidelberg University Hospital|Munich/ Heidelberg|Germany      
Berend Isermann|Otto-von-Guericke-University Magdeburg|Magdeburg|Germany      
Rohit N Kulkarni|Czech Academy of Sciences (CAS)|Prague|Czech Republic      
Rohit N Kulkarni|Harvard Medical School|Boston|USA      
George Kunos|National Institutes of Health (NIH) - NIAAA|Bethesda|USA      
Tony Lam|Toronto General Research Institute and Department of Medicine|Toronto|Canada      
Susanne Mandrup|University of Southern Denmark|Odense|Denmark      
Alexander Pfeifer|University of Bonn|Bonn|Germany      
Michael Potente|Max Planck Institute for Heart and Lung Research|Bad Nauheim|Germany      
Matthew Poy|Max-Delbrück-Center for Molecular Medicine (MDC)|Berlin|Germany      
Michael Ristow|ETH Zurich|Zurich|Switzerland      
Alan Saltiel|University of California|La Jolla|US      
Aurelio Teleman|German Cancer Research Center (DKFZ)|Heidelberg|Germany      
Frederic Tessier|Lille 2 University|Lille|France      
Paul Thornalley|University of Warwick|Coventry|UK      
Emmanuel van Obberghen|University of Nice|Nice|France      
Erwin Wagner|CNIO - Centro Nacional de Investigaciones Oncologicas|Madrid|Spain      
Siu Ling Wong|Harvard Medical School|Boston|USA      
Giles Yeo|University of Cambridge|Cambridge|UK      

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Program - Thursday, October 6

08.00 - 08.50|Registration  
08.50|Welcome Stephan Herzig, Helmholtz Zentrum München, Institute for Diabetes and Cancer, Munich  
09.00 - 12.30|Session I: Novel concepts derived from clinical studies  
09.00|Essential role of peripheral cannabinoid-1 receptors in type-2 diabetes and diabetic nephropathy George Kunos, National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda  
09.30|Prenatal environment and diabetes: possible role of microRNAs
Emmanuel Van Obberghen, Department of Medical Research IRCAN Medical School, Nice  
10.00|Inflammatory links between obesity and diabetes Alan Saltiel, UC San Diego Institute for Diabetes and Metabolic Health (IDMH), La Jolla  
10.30|Coffee break  
11.00|Using iPS cells to interrogate diabetes complications Rohit N Kulkarni, Joslin Diabetes Center- Harvard Medical School, Boston  
11.30|Targeting BAT as a new approach to tackle diabetes Alexander Pfeifer, University of  Bonn, Bonn  
12.00 - 12.30|Short Talks I  
12.00|Reduced glyoxalase 1 activity in carotid artery plaques of non-diabetic patients with increased HbA1c Andreas Peters, University of Heidelberg, Heidelberg  
12.15|Impact of the glyoxalase system on organ development and function under diabetic conditions in zebrafish Elisabeth Lodd, Medical Faculty Mannheim, Heidelberg University, Mannheim  
12.30 - 14.30|Lunch break and poster session Posters are displayed in Foyer  
14.30 - 18.00|Session II: Genetics and Epigenetics of diabetic complications  
14.30|"Genetic susceptibility to diabetes  Philippe Froguel, Imperial College London, London/ Lille University, Lille"  
15.00|New Genetic and Epigenetic insights into Metabolism and Diabetes Martin Hrabe de Angelis, Helmholtz Zentrum München, Institute of Experimental Genetics, Munich/ Neuherberg  
15.30|Genetics of obesity: Can an old dog teach us new tricks? Giles Yeo, University of Cambridge, Cambridge  
16.00|Coffee break  
16.30|Transcriptional networks regulation adipocyte differentiation and function Susanne Mandrup, University of Southern Denmark, Odense  
17.00|The regulatory role of Argonaute2 in glucose and lipid metabolism Matthew Poy, Max Delbrueck Center for Molecular Medicine, Berlin  
17.30 - 18.00|Short Talks II  
17.30|Transforming Growth Factor Beta-like stimulated clone 22 D4 promotes diabetic hyperglycemia and insulin resistance  Bilgen E. Uestuenel, Heidelberg – IDC Translational Diabetes Program, Heidelberg University Hospital, Heidelberg  
17.45|Crosstalk of fatty liver with renal sinus fat impairs renal function and glomerular cell integrity Erwin Schleicher, University of Tuebingen, Tuebingen  
18.00|End of Session



Program - Friday, October 7

08.00 - 08.50|Registration  
09.00 - 12.30|Session III: Emerging concepts in vascular dysfunction  
09.00|Regulation of endothelial quiescence by metabolites Michael Potente, Max Planck Institute for Heart and Lung Research, Bad Nauheim  
09.30|Delayed wound healing in diabetes: The impact of NETs  Siu Ling Wong, Harvard Medical School, Boston  
10.00|Perivascular Adipose Tissue and Arterial Function in Health and Obesity Anthony Heagerty, University of Manchester , Manchester  
10.30|Coffee break  
11.00|Metabolic Stress in the Control of Healthspan Michael Ristow, ETH Zurich, Zurich  
11.30|Proteostasis in diabetic nephropathy Berend Isermann, Otto-von-Guericke-University Magdeburg, Magdeburg  
12.00 - 12.30|Short Talks III  
12.00|Vascular complications associated with gestational diabetic mothers and their newborn Halime Kenar, Kocaeli University, Kocaeli  
12.15|Oxidative stress and biochemical markers of vascular disease in Type 1 diabetes mellitus Jan Skrha, Charles University, Prague  
12.30 - 14.30|Lunch break and poster session Posters are displayed in Foyer  
14.30 - 16.00|Session IV: Organ-Metabolism Crosstalk  
14.30|Impaired methylglyoxal detoxification recapitulates progression of Type 2 Diabetes Aurelio Teleman, German Cancer Research Center (DKFZ), Heidelberg  
15.00|Brain-Liver Axis Tony Lam, Toronto General Research Institute (TGRI), Toronto  
15.30|Inflammation and metabolic dysfunction Erwin Wagner, Spanish National Cancer Research Center, Madrid  
16.00|End of Sessions  
16.00 – 16.30|Coffee break  
16.30 – 17.00|EASD Business Meeting  



Program - Saturday, October 8

08.00 - 08.50|Registration  
09.00 - 12.30|Session V: EASD  
09.00|Glyoxalase 1 inducers - a new treatment for diabetic complications? Paul Thornalley,  University of Warwick, Coventry  
09.30|The liver as a regulator of diabetic complications Stephan Herzig, Helmholtz Zentrum München, Institute for Diabetes and Cancer, Munich  
10.00|Effect of Gastric Bypass Surgery on Experimental Diabetic Kidney Disease Neil Docherty, University College Dublin, Dublin  
10.30 - 11.00|Short  Talk  EASD  
|Dicarbonyl stress in periodontitis – the fifth complication of diabetes Naila Rabbani, University of Warwick, Coventry  
10.45 - 11.00|Coffee break  
10.30 - 11.30|Poster Session EASD Posters are displayed in Foyer  
11.30|AGEs, can we eat diabetes? Frederic Tessier, Lille 2 University, Lille  
12.00|Does Epigenetics account for Diabetes (and Comorbidity) Risk? Francesco Beguinot, Federico II University of  Naples, Naples  
12.30 - 13.30|Farewell