HiDC 2015

2nd Heidelberg International Symposium 
on Diabetic Complications 

16. und 17.10.2015

The conference will highlight recent exciting developments in key areas of vascular biology and diabetes, including current progress in vascular-metabolic aspects and clinical perspectives in the treatment of diabetes and its long-term complications. We envision contributions allowing the audience to gain an overview of the recent progress on these fundamental topics in biomedicine.

Invited Speakers

Sven Enerbäck|University of Gothenburg|Gothenburg|Sweden      
Per-Henrik Groop|Helsinki University|Helsinki|Finland      
Katerina Kankova|Masaryk University|Brno|Czech Republic      
George Kunos|National Institutes of Health (NIH) - NIAAA|Rockville|USA      
Eckhard Lammert|Heinrich-Heine-Universität|Dusseldorf|Germany      
Michael Potente|Max Planck Institute for Heart and Lung Research|Bad Nauheim|Germany      
Klaus Preissner|Justus-Liebig-University|Giessen|Germany      
Peter Rossing|Aarhus University/ Steno Diabetes Center A/S|Gentofte|Denmark      
Christiana Ruhrberg|University College London|London|UK      
Alan Stitt|Queen's University Belfast|Belfast|UK      
Paul Thornalley|University of Warwick|Coventry|UK      
Karl Tryggvason|Karolinska Institut & Duke-NUS|Stockholm & Singapore|Sweden & Singapore      
Antonio Vidal-Puig|University of Cambridge|Cambridge|UK      
Kenneth Walsh|Boston University School of Medicine|Boston|US      
Christian Weber|Ludwig-Maximilians-University|Munich|      

Nach oben

Program - Friday, October 16

08.00 - 08.50|Registration  
08.50|Welcome Stephan Herzig, Helmholtz Zentrum München, Institute for Diabetes and Cancer, Munich  
09.00 - 12.30|Session I: Emerging molecular concepts in diabetic vascular dysfunction  
09.00|Neuropilin signaling in vascular eye pathology Christiana Ruhrberg  
09.30|Innate immune responses and Diabetic Retinopathy Alan Stitt  
10.00|Metabolic regulation of endothelial growth and quiescence Michael Potente  
10.30|Coffee break  
11.00|Diabetic nephropathy susceptibility genes Karl Tryggvason  
11.30|New treatment options in diabetic nephropathy Peter Rossing  
12.00 - 12.30|Poster Talks I  
12.00|Cation channels of the TRPC family contribute to development of nephropathy and retinopathy in the STZ model Dagmar Schumacher  
12.10|Hyperglycemic memory - Mechanisms relevant to the diabetic retina Patrick Friedrichs  
12.20|Anks6(p.R823W)  overexpression in kidney affects retinal degeneration Jihong Lin  
12.30 - 14.30|Lunch break and poster session Posters are displayed in Foyer  
14.30 - 18.00|Session II: Stress signaling pathways in diabetic complications  
14.30|Alarming news and views of extracellular RNA in inflammation and vascular remodeling Klaus T. Preissner  
15.00|Novel antifibrotic treatment strategy using peripheral CB1 receptor inhibitors with secondary targets Georg Kunos  
15.30|Dicarbonyl stress and glyoxalase 1 in the development of vascular complications of diabetes Paul Thornalley  
16.00|Coffee break  
16.30|Glyoxalase system in clinically relevant metabolic stresses in diabetes: hyperglycemia, high glucose variability, lipotoxicity and uremia Katerina Kankova  
17.00|Adipokine links between metabolic and cardiovascular disease Kenneth Walsh  
17.30 - 18.00|Poster Talks II  
17.30|Age-related carbonylation in glomeruli of diabetic mice influences anti-oxidative defense mechanisms Tanja Wiedenmann  
17.40|Microvascular reactivity relates to the skin autofluorescence but not to soluble receptor for advanced glycation endproducts in patients with diabetes Jan Škrha jr.  
17.50|Post-glucose load plasma α-dicarbonyl concentrations are increased in individuals with impaired glucose metabolism and type 2 diabetes: The CODAM study Dionne Maessen  

Program - Saturday, October 17

08.00 - 08.50|Registration  
09.00 - 12.30|Session III: Beyond complications  
09.00|Diabetic nephropathy – genes or the environment? Per-Henrik Groop  
09.30|Brown adipose tissue - of mice and men Sven Enerbäck  
10.00|Adipose tissue expandibility, lipotoxicity and the metabolic syndrome  Antonio Vidal-Puig  
10.30|Coffee break  
11.00|Novel targets for vascular protection Christian Weber  
11.30|NMDA-receptors - novel drug targets for diabetes treatment Eckhard Lammert  
12.00 - 12.30|Poster Talks III  
12.00|Hypoxia plays a key role in the accumulation of carbonyl stress in obese adipose tissue Katrien Gaens  
12.10|The association between dietary intake of advanced glycation endproducts and plasma levels of advanced glycation endproducts: THE CODAM STUDY Jean Scheijen  
12.20|Advanced glycation end-products as long-term retrospective indicators of glycemic balance in children with non-complicated type 1 diabetes mellitus Stéphane Jaisson  
12.30|Concluding remarks Peter Nawroth  
12.40 - 14.30|Lunch break and poster session Posters are displayed in Foyer  
14.30 - 16.00|EASD Study Group Talks  
14.30|Skin AGEs and skin fluorescence in the progression of micro- and macrovascular complications in Type 1 diabetes: The plot thickens Vincent Monnier  
14.50|Methylglyoxal modification of low density lipoprotein – a novel route to the pro-atherogenic, small dense LDL with increased arterial proteoglycan binding and aortal retention Naila Rabbani  
15.10|Over-expression of the AGE receptor (AGE-R1) during high age feeding results in hepatic fibrosis and exacerbates glucose intolerance Josephine Forbes  
15.30|Centrally obese women present low sRAGE but unaltered SSAO/sVAP-1 levels regardless of presence/absence of additional cardiometabolic risk factors Katerina Šebeková  
16.00 - 16.30|Coffee break  
16.30 - 17.30|EASD Business Meeting