Wohlfart, D. P., Lou, B., Middel, C. S., Morgenstern, J., Fleming, T., Sticht, C., Hausser, I., Hell, R., Hammes, H. P., Szendrödi, J., Nawroth, P. P., & Kroll, J. (2022). Accumulation of acetaldehyde in aldh2.1-/- zebrafish causes increased retinal angiogenesis and impaired glucose metabolism. Redoxbiology, 50, 102249. https://doi.org/10.1016/j.redox.2022.102249

Loft, A., Schmidt, S. F., Caratti, G., Stifel, U., Havelund, J., Sekar, R., Kwon, Y., Sulaj, A., Chow, K. K., Alfaro, A. J., Schwarzmayr, T., Rittig, N., Svart, M., Tsokanos, F. F., Maida, A., Blutke, A., Feuchtinger, A., Møller, N., Blüher, M., Nawroth, P., Szendroedi, J., Færgeman, N. J., Zeigerer, A., Tuckermann, J., & Herzig, S. (2022). A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis. Cell metabolism, 34(3), 473–486.e9. https://doi.org/10.1016/j.cmet.2022.01.004

Foesleitner, O., Sulaj, A., Sturm, V., Kronlage, M., Godel, T., Preisner, F., Nawroth, P. P., Bendszus, M., Heiland, S., & Schwarz, D. (2022). Diffusion MRI in Peripheral Nerves: Optimized b Values and the Role of Non-Gaussian Diffusion. Radiology, 302(1), 153–161. https://doi.org/10.1148/radiol.2021204740

Cortizo, F. G., Pfaff, D., Wirth, A., Schlotterer, A., Medert, R., Morgenstern, J., Weber, T., Hammes, H. P., Fleming, T., Nawroth, P. P., Freichel, M., & Teleman, A. A. (2022). The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136. Molecular metabolism55, 101406. https://doi.org/10.1016/j.molmet.2021.101406

Heremans, I. P., Caligiore, F., Gerin, I., Bury, M., Lutz, M., Graff, J., Stroobant, V., Vertommen, D., Teleman, A. A., Van Schaftingen, E., & Bommer, G. T. (2022). Parkinson's disease protein PARK7 prevents metabolite and protein damage caused by a glycolytic metabolite. Proceedings of the National Academy of Sciences of the United States of America119(4), e2111338119. https://doi.org/10.1073/pnas.2111338119

Wiggenhauser, L. M., Metzger, L., Bennewitz, K., Soleymani, S., Boger, M., Tabler, C. T., Hausser, I., Sticht, C., Wohlfart, P., Volk, N., Heidenreich, E., Buettner, M., Hammes, H. P., & Kroll, J. (2022). pdx1 Knockout Leads to a Diabetic Nephropathy-Like Phenotype in Zebrafish and Identifies Phosphatidylethanolamine as Metabolite Promoting Early Diabetic Kidney Damage. Diabetes, db210645. Advance online publication. https://doi.org/10.2337/db21-0645

Morgenstern, J., Groener, J. B., Jende, J., Kurz, F. T., Strom, A., Göpfert, J., Kender, Z., Le Marois, M., Brune, M., Kuner, R., Herzig, S., Roden, M., Ziegler, D., Bendszus, M., Szendroedi, J., Nawroth, P., Kopf, S., & Fleming, T. (2021). Neuron-specific biomarkers predict hypo- and hyperalgesia in individuals with diabetic peripheral neuropathy. Diabetologia64(12), 2843–2855. https://doi.org/10.1007/s00125-021-05557-6

Pasricha, S. R., Tye-Din, J., Muckenthaler, M. U., & Swinkels, D. W. (2021). Iron deficiency. Lancet (London, England)397(10270), 233–248. https://doi.org/10.1016/S0140-6736(20)32594-0

Tsokanos, F. F., Muley, C., Khani, S., Hass, D., Fleming, T., Wolff, G., Bartelt, A., Nawroth, P., & Herzig, S. (2021). Methylglyoxal Drives a Distinct, Nonclassical Macrophage Activation Status. Thrombosis and haemostasis121(11), 1464–1475. https://doi.org/10.1055/s-0041-1726346

Colucci, S., Altamura, S., Marques, O., Dropmann, A., Horvat, N. K., Müdder, K., Hammad, S., Dooley, S., & Muckenthaler, M. U. (2021). Liver Sinusoidal Endothelial Cells Suppress Bone Morphogenetic Protein 2 Production in Response to TGFβ Pathway Activation. Hepatology (Baltimore, Md.)74(4), 2186–2200. https://doi.org/10.1002/hep.3190

Heinkele, F. J., Lou, B., Erben, V., Bennewitz, K., Poschet, G., Sticht, C., & Kroll, J. (2021). Metabolic and Transcriptional Adaptations Improve Physical Performance of Zebrafish. Antioxidants (Basel, Switzerland)10(10), 1581. https://doi.org/10.3390/antiox10101581

Altamura, S., Müdder, K., Schlotterer, A., Fleming, T., Heidenreich, E., Qiu, R., Hammes, H. P., Nawroth, P., & Muckenthaler, M. U. (2021). Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload. Molecular metabolism51, 101235. https://doi.org/10.1016/j.molmet.2021.101235

Heidenreich, E., Pfeffer, T., Kracke, T., Mechtel, N., Nawroth, P., Hoffmann, G. F., Schmitt, C. P., Hell, R., Poschet, G., & Peters, V. (2021). A Novel UPLC-MS/MS Method Identifies Organ-Specific Dipeptide Profiles. International journal of molecular sciences22(18), 9979. https://doi.org/10.3390/ijms22189979

Qi, H., Schmöhl, F., Li, X., Qian, X., Tabler, C. T., Bennewitz, K., Sticht, C., Morgenstern, J., Fleming, T., Volk, N., Hausser, I., Heidenreich, E., Hell, R., Nawroth, P. P., & Kroll, J. (2021). Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations. Advanced science (Weinheim, Baden-Wurttemberg, Germany)8(18), e2101281. https://doi.org/10.1002/advs.202101281

Shahzad, K., Fatima, S., Al-Dabet, M. M., Gadi, I., Khawaja, H., Ambreen, S., Elwakiel, A., Klöting, N., Blüher, M., Nawroth, P. P., Mertens, P. R., Michel, S., Jaschinski, F., Klar, R., & Isermann, B. (2021). CHOP-ASO Ameliorates Glomerular and Tubular Damage on Top of ACE Inhibition in Diabetic Kidney Disease. Journal of the American Society of Nephrology : JASN, 32(12), 3066–3079. Advance online publication. https://doi.org/10.1681/ASN.2021040431

Bartosova, M., Zhang, C., Schaefer, B., Herzog, R., Ridinger, D., Damgov, I., Levai, E., Marinovic, I., Eckert, C., Romero, P., Sallay, P., Ujszaszi, A., Unterwurzacher, M., Wagner, A., Hildenbrand, G., Warady, B. A., Schaefer, F., Zarogiannis, S. G., Kratochwill, K., & Schmitt, C. P. (2021). Glucose Derivative Induced Vasculopathy in Children on Chronic Peritoneal Dialysis. Circulation research129(5), e102–e118. https://doi.org/10.1161/CIRCRESAHA.121.319310

Loft, A., Alfaro, A. J., Schmidt, S. F., Pedersen, F. B., Terkelsen, M. K., Puglia, M., Chow, K. K., Feuchtinger, A., Troullinaki, M., Maida, A., Wolff, G., Sakurai, M., Berutti, R., Ekim Üstünel, B., Nawroth, P., Ravnskjaer, K., Diaz, M. B., Blagoev, B., & Herzig, S. (2021). Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication. Cell metabolism, 33(8), 1685–1700.e9. https://doi.org/10.1016/j.cmet.2021.06.005

Bali, K. K., Gandla, J., Rangel, D. R., Castaldi, L., Mouritzen, P., Agarwal, N., Schmelz, M., Heppenstall, P., & Kuner, R. (2021). A genome-wide screen reveals microRNAs in peripheral sensory neurons driving painful diabetic neuropathy. Pain162(5), 1334–1351. https://doi.org/10.1097/j.pain.0000000000002159

Medert, R., Jungmann, A., Hildebrand, S., Busch, M., Grimm, D., Flockerzi, V., Müller, O. J., Most, P., Schumacher, D., & Freichel, M. (2021). Development of an AAV9-RNAi-mediated silencing strategy to abrogate TRPM4 expression in the adult heart. Pflugers Archiv473(3), 533–546. https://doi.org/10.1007/s00424-021-02521-6

Bühler, L., Maida, A., Vogl, E. S., Georgiadi, A., Takacs, A., Kluth, O., Schürmann, A., Feuchtinger, A., von Toerne, C., Tsokanos, F. F., Klepac, K., Wolff, G., Sakurai, M., Ekim Üstünel, B., Nawroth, P., & Herzig, S. (2021). Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control. Life science alliance4(4), e202000898. https://doi.org/10.26508/lsa.202000898

Chen, J., Fleming, T., Katz, S., Dewenter, M., Hofmann, K., Saadatmand, A., Kronlage, M., Werner, M. P., Pokrandt, B., Schreiter, F., Lin, J., Katz, D., Morgenstern, J., Elwakiel, A., Sinn, P., Gröne, H. J., Hammes, H. P., Nawroth, P. P., Isermann, B., Sticht, C., … Backs, J. (2021). CaM Kinase II-δ Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy. Diabetes70(2), 616–626. https://doi.org/10.2337/db19-0659

Gadi, I., Fatima, S., Elwakiel, A., Nazir, S., Mohanad Al-Dabet, M., Rana, R., Bock, F., Manoharan, J., Gupta, D., Biemann, R., Nieswandt, B., Braun-Dullaeus, R., Besler, C., Scholz, M., Geffers, R., Griffin, J. H., Esmon, C. T., Kohli, S., Isermann, B.*, & Shahzad, K*. (2021). Different DOACs Control Inflammation in Cardiac Ischemia-Reperfusion Differently. Circulation research, 128(4), 513–529. https://doi.org/10.1161/CIRCRESAHA.120.317219
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Deshpande, D., Agarwal, N., Fleming, T., Gaveriaux-Ruff, C., Klose, C., Tappe-Theodor, A., Kuner, R., & Nawroth, P. (2021). Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy. Nature communications12(1), 426. doi.org/10.1038/s41467-020-20677-0

Finnerup, N. B., Kuner, R., & Jensen, T. S. (2021). Neuropathic Pain: From Mechanisms to Treatment. Physiological reviews101(1), 259–301. https://doi.org/10.1152/physrev.00045.2019

Morgenstern, J., Fleming, T., Kliemank, E., Brune, M., Nawroth, P., & Fischer, A. (2021). Quantification of All-Trans Retinoic Acid by Liquid Chromatography-Tandem Mass Spectrometry and Association with Lipid Profile in Patients with Type 2 Diabetes. Metabolites11(1), 60. https://doi.org/10.3390/metabo11010060

Li, X., Schmöhl, F., Qi, H., Bennewitz, K., Tabler, C. T., Poschet, G., Hell, R., Volk, N., Poth, T., Hausser, I., Morgenstern, J., Fleming, T., Nawroth, P. P., & Kroll, J. (2020). Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish. iScience23(12), 101763. https://doi.org/10.1016/j.isci.2020.101763

Medert, R., Pironet, A., Bacmeister, L., Segin, S., Londoño, J., Vennekens, R., & Freichel, M. (2020). Genetic background influences expression and function of the cation channel TRPM4 in the mouse heart. Basic research in cardiology115(6), 70. https://doi.org/10.1007/s00395-020-00831-x

Lou, B., Boger, M., Bennewitz, K., Sticht, C., Kopf, S., Morgenstern, J., Fleming, T., Hell, R., Yuan, Z., Nawroth, P. P., & Kroll, J. (2020). Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox biology37, 101723. https://doi.org/10.1016/j.redox.2020.101723

Morgenstern, J., Campos Campos, M., Nawroth, P., & Fleming, T. (2020). The Glyoxalase System-New Insights into an Ancient Metabolism. Antioxidants (Basel, Switzerland)9(10), 939. https://doi.org/10.3390/antiox9100939

Agarwal, N., Taberner, F. J., Rangel Rojas, D., Moroni, M., Omberbasic, D., Njoo, C., Andrieux, A., Gupta, P., Bali, K. K., Herpel, E., Faghihi, F., Fleming, T., Dejean, A., Lechner, S. G., Nawroth, P. P., Lewin, G. R., & Kuner, R. (2020). SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes. Neuron107(6), 1141–1159.e7. https://doi.org/10.1016/j.neuron.2020.06.037

Brings, S., Fleming, T., Herzig, S., Nawroth, P. P., & Kopf, S. (2020). Urinary cathepsin L is predictive of changes in albuminuria and correlates with glucosepane in patients with type 2 diabetes in a closed-cohort study. Journal of diabetes and its complications34(9), 107648. https://doi.org/10.1016/j.jdiacomp.2020.107648

Morgenstern, J., Katz, S., Krebs-Haupenthal, J., Chen, J., Saadatmand, A., Cortizo, F. G., Moraru, A., Zemva, J., Campos, M. C., Teleman, A., Backs, J., Nawroth, P., & Fleming, T. (2020). Phosphorylation of T107 by CamKIIδ Regulates the Detoxification Efficiency and Proteomic Integrity of Glyoxalase 1. Cell reports32(12), 108160. https://doi.org/10.1016/j.celrep.2020.108160

Hirth, M., Gandla, J., Höper, C., Gaida, M. M., Agarwal, N., Simonetti, M., Demir, A., Xie, Y., Weiss, C., Michalski, C. W., Hackert, T., Ebert, M. P., & Kuner, R. (2020). CXCL10 and CCL21 Promote Migration of Pancreatic Cancer Cells Toward Sensory Neurons and Neural Remodeling in Tumors in Mice, Associated With Pain in Patients. Gastroenterology159(2), 665–681.e13. https://doi.org/10.1053/j.gastro.2020.04.037

Madhusudhan, T., Ghosh, S., Wang, H., Dong, W., Gupta, D., Elwakiel, A., Stoyanov, S., Al-Dabet, M. M., Krishnan, S., Biemann, R., Nazir, S., Zimmermann, S., Mathew, A., Gadi, I., Rana, R., Zeng-Brouwers, J., Moeller, M. J., Schaefer, L., Esmon, C. T., Kohli, S., Reiser, J., Rezaie, A.R., Ruf, W., Isermann, B. (2020). Podocyte Integrin-β3 and Activated Protein C Coordinately Restrict RhoA Signaling and Ameliorate Diabetic Nephropathy. Journal of the American Society of Nephrology : JASN, 31(8), 1762–1780. https://doi.org/10.1681/ASN.2019111163

Vinchi, F., Porto, G., Simmelbauer, A., Altamura, S., Passos, S. T., Garbowski, M., Silva, A., Spaich, S., Seide, S. E., Sparla, R., Hentze, M. W., & Muckenthaler, M. U. (2020). Atherosclerosis is aggravated by iron overload and ameliorated by dietary and pharmacological iron restriction. European heart journal41(28), 2681–2695. https://doi.org/10.1093/eurheartj/ehz112

Weigand, T., Colbatzky, F., Pfeffer, T., Garbade, S. F., Klingbeil, K., Colbatzky, F., Becker, M., Zemva, J., Bulkescher, R., Schürfeld, R., Thiel, C., Volk, N., Reuss, D., Hoffmann, G. F., Freichel, M., Hecker, M., Poth, T., Fleming, T., Poschet, G., Schmitt, C. P., … Peters, V. (2020). A Global Cndp1-Knock-Out Selectively Increases Renal Carnosine and Anserine Concentrations in an Age- and Gender-Specific Manner in Mice. International journal of molecular sciences21(14), 4887. https://doi.org/10.3390/ijms21144887

Kumar, V., Agrawal, R., Pandey, A., Kopf, S., Hoeffgen, M., Kaymak, S., Bandapalli, O. R., Gorbunova, V., Seluanov, A., Mall, M. A., Herzig, S., & Nawroth, P. P. (2020). Compromised DNA repair is responsible for diabetes-associated fibrosis. The EMBO journal39(11), e103477. https://doi.org/10.15252/embj.2019103477

Schwarz, D., Hidmark, A. S., Sturm, V., Fischer, M., Milford, D., Hausser, I., Sahm, F., Breckwoldt, M. O., Agarwal, N., Kuner, R., Bendszus, M., Nawroth, P. P., Heiland, S., & Fleming, T. (2020). Characterization of experimental diabetic neuropathy using multicontrast magnetic resonance neurography at ultra high field strength. Scientific reports10(1), 7593. https://doi.org/10.1038/s41598-020-64585-1

Wiggenhauser, L. M., Qi, H., Stoll, S. J., Metzger, L., Bennewitz, K., Poschet, G., Krenning, G., Hillebrands, J. L., Hammes, H. P., & Kroll, J. (2020). Activation of Retinal Angiogenesis in Hyperglycemic pdx1-/- Zebrafish Mutants. Diabetes69(5), 1020–1031. https://doi.org/10.2337/db19-0873

Sanlialp, A., Schumacher, D., Kiper, L., Varma, E., Riechert, E., Ho, T. C., Hofmann, C., Kmietczyk, V., Zimmermann, F., Dlugosz, S., Wirth, A., Gorska, A. A., Burghaus, J., Camacho Londoño, J. E., Katus, H. A., Doroudgar, S., Freichel, M., & Völkers, M. (2020). Saraf-dependent activation of mTORC1 regulates cardiac growth. Journal of molecular and cellular cardiology141, 30–42. https://doi.org/10.1016/j.yjmcc.2020.03.004

Schmöhl, F., Peters, V., Schmitt, C. P., Poschet, G., Büttner, M., Li, X., Weigand, T., Poth, T., Volk, N., Morgenstern, J., Fleming, T., Nawroth, P. P., & Kroll, J. (2019). CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications. Cellular and molecular life sciences : CMLS76(22), 4551–4568. https://doi.org/10.1007/s00018-019-03127-z

Altamura, S., Schaeper, U., Dames, S., Löffler, K., Eisermann, M., Frauendorf, C., Müdder, K., Neves, J., & Muckenthaler, M. U. (2019). SLN124, a GalNAc-siRNA Conjugate Targeting TMPRSS6, Efficiently Prevents Iron Overload in Hereditary Haemochromatosis Type 1. HemaSphere3(6), e301. https://doi.org/10.1097/HS9.0000000000000301

Groener, J. B., Oikonomou, D., Cheko, R., Kender, Z., Zemva, J., Kihm, L., Muckenthaler, M., Peters, V., Fleming, T., Kopf, S., & Nawroth, P. P. (2019). Methylglyoxal and Advanced Glycation End Products in Patients with Diabetes - What We Know so Far and the Missing Links Exp Clin Endocrinol Diabetes127(8), 497–504. https://doi.org/10.1055/s-0043-106443

Kronlage, M., Dewenter, M., Grosso, J., Fleming, T., Oehl, U., Lehmann, L. H., Falcão-Pires, I., Leite-Moreira, A. F., Volk, N., Gröne, H. J., Müller, O. J., Sickmann, A., Katus, H. A., & Backs, J. (2019). O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart From Failure. Circulation140(7), 580–594. https://doi.org/10.1161/CIRCULATIONAHA.117.031942

Thielmann, C. M., Costa da Silva, M., Muley, T., Meister, M., Herpel, E., & Muckenthaler, M. U. (2019). Iron accumulation in tumor-associated macrophages marks an improved overall survival in patients with lung adenocarcinoma. Scientific reports9(1), 11326. https://doi.org/10.1038/s41598-019-47833-x

Rojas, D. R., Kuner, R., & Agarwal, N. (2019). Metabolomic signature of type 1 diabetes-induced sensory loss and nerve damage in diabetic neuropathy. Journal of molecular medicine (Berlin, Germany)97(6), 845–854. https://doi.org/10.1007/s00109-019-01781-1

Frank, T., Nawroth, P., & Kuner, R. (2019). Structure-function relationships in peripheral nerve contributions to diabetic peripheral neuropathy. Pain160 Suppl 1, S29–S36. https://doi.org/10.1097/j.pain.0000000000001530

Zemva, J., Pfaff, D., Groener, J. B., Fleming, T., Herzig, S., Teleman, A., Nawroth, P. P., & Tyedmers, J. (2019). Effects of the Reactive Metabolite Methylglyoxal on Cellular Signalling, Insulin Action and Metabolism - What We Know in Mammals and What We Can Learn From Yeast. Exp Clin Endocrinol Diabetes127(4), 203–214. https://doi.org/10.1055/s-0043-122382

Sachdeva, R., Fleming, T., Schumacher, D., Homberg, S., Stilz, K., Mohr, F., Wagner, A. H., Tsvilovskyy, V., Mathar, I., & Freichel, M. (2019). Methylglyoxal evokes acute Ca2+ transients in distinct cell types and increases agonist-evoked Ca2+ entry in endothelial cells via CRAC channels. Cell calcium78, 66–75. https://doi.org/10.1016/j.ceca.2019.01.002

Rojas, D. R., Tegeder, I., Kuner, R., & Agarwal, N. (2018). Hypoxia-inducible factor 1α protects peripheral sensory neurons from diabetic peripheral neuropathy by suppressing accumulation of reactive oxygen species. Journal of molecular medicine (Berlin, Germany)96(12), 1395–1405. https://doi.org/10.1007/s00109-018-1707-9

Schumacher, D., Morgenstern, J., Oguchi, Y., Volk, N., Kopf, S., Groener, J. B., Nawroth, P. P., Fleming, T., & Freichel, M. (2018). Compensatory mechanisms for methylglyoxal detoxification in experimental & clinical diabetes. Molecular metabolism18, 143–152. https://doi.org/10.1016/j.molmet.2018.09.005

Micakovic, T., Papagiannarou, S., Clark, E., Kuzay, Y., Abramovic, K., Peters, J., Sticht, C., Volk, N., Fleming, T., Nawroth, P., Hammes, H. P., Alenina, N., Gröne, H. J., & Hoffmann, S. C. (2018). The angiotensin II type 2 receptors protect renal tubule mitochondria in early stages of diabetes mellitus. Kidney international94(5), 937–950. https://doi.org/10.1016/j.kint.2018.06.006

Nawroth, P. P., Bendszus, M., Pham, M., Jende, J., Heiland, S., Ries, S., Schumann, C., Schmelz, M., Schuh-Hofer, S., Treede, R. D., Kuner, R., Oikonomou, D., Groener, J. B., & Kopf, S. (2018). The Quest for more Research on Painful Diabetic Neuropathy. Neuroscience387, 28–37. https://doi.org/10.1016/j.neuroscience.2017.09.023

Peters, V., Calabrese, V., Forsberg, E., Volk, N., Fleming, T., Baelde, H., Weigand, T., Thiel, C., Trovato, A., Scuto, M., Modafferi, S., & Schmitt, C. P. (2018). Protective Actions of Anserine Under Diabetic Conditions. International journal of molecular sciences19(9), 2751. https://doi.org/10.3390/ijms19092751

Senyilmaz-Tiebe, D., Pfaff, D. H., Virtue, S., Schwarz, K. V., Fleming, T., Altamura, S., Muckenthaler, M. U., Okun, J. G., Vidal-Puig, A., Nawroth, P., & Teleman, A. A. (2018). Dietary stearic acid regulates mitochondria in vivo in humans. Nature communications9(1), 3129. https://doi.org/10.1038/s41467-018-05614-6

Shahzad, K., Gadi, I., Nazir, S., Al-Dabet, M. M., Kohli, S., Bock, F., Breitenstein, L., Ranjan, S., Fuchs, T., Halloul, Z., Nawroth, P. P., Pelicci, P. G., Braun-Dullaeus, R. C., Camerer, E., Esmon, C. T., & Isermann, B. (2018). Activated protein C reverses epigenetically sustained p66Shc expression in plaque-associated macrophages in diabetes. Communications biology, 1, 104. https://doi.org/10.1038/s42003-018-0108-5

Kopf, S., Groener, J. B., Kender, Z., Fleming, T., Brune, M., Riedinger, C., Volk, N., Herpel, E., Pesta, D., Szendrödi, J., Wielpütz, M. O., Kauczor, H. U., Katus, H. A., Kreuter, M., & Nawroth, P. P. (2018). Breathlessness and Restrictive Lung Disease: An Important Diabetes-Related Feature in Patients with Type 2 Diabetes. Respiration96(1), 29–40. https://doi.org/10.1159/000488909

Andersen, S. T., Witte, D. R., Dalsgaard, E. M., Andersen, H., Nawroth, P., Fleming, T., Jensen, T. M., Finnerup, N. B., Jensen, T. S., Lauritzen, T., Feldman, E. L., Callaghan, B. C., & Charles, M. (2018). Risk Factors for Incident Diabetic Polyneuropathy in a Cohort With Screen-Detected Type 2 Diabetes Followed for 13 Years: ADDITION-Denmark. Diabetes care41(5), 1068–1075. https://doi.org/10.2337/dc17-2062

Moraru, A., Wiederstein, J., Pfaff, D., Fleming, T., Miller, A. K., Nawroth, P., & Teleman, A. A. (2018). Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes. Cell metabolism27(4), 926–934.e8. https://doi.org/10.1016/j.cmet.2018.02.003

Weigand, T., Singler, B., Fleming, T., Nawroth, P., Klika, K. D., Thiel, C., Baelde, H., Garbade, S. F., Wagner, A. H., Hecker, M., Yard, B. A., Amberger, A., Zschocke, J., Schmitt, C. P., & Peters, V. (2018). Carnosine Catalyzes the Formation of the Oligo/Polymeric Products of Methylglyoxal. Cell Physiol Biochem., 46(2), 713–726. https://doi.org/10.1159/000488727

She, J., Yuan, Z., Wu, Y., Chen, J., & Kroll, J. (2018). Targeting erythropoietin protects against proteinuria in type 2 diabetic patients and in zebrafish. Molecular metabolism8, 189–202. https://doi.org/10.1016/j.molmet.2017.11.006

Morgenstern, J., Fleming, T., Kadiyska, I., Brings, S., Groener, J. B., Nawroth, P., Hecker, M., & Brune, M. (2018). Sensitive mass spectrometric assay for determination of 15-deoxy-Δ12,14-prostaglandin J2 and its application in human plasma samples of patients with diabetes. Analytical and bioanalytical chemistry410(2), 521–528. https://doi.org/10.1007/s00216-017-0748-1

Altamura, S., Kopf, S., Schmidt, J., Müdder, K., da Silva, A. R., Nawroth, P., & Muckenthaler, M. U. (2017). Uncoupled iron homeostasis in type 2 diabetes mellitus. Journal of molecular medicine (Berlin, Germany)95(12), 1387–1398. https://doi.org/10.1007/s00109-017-1596-3

Marquardt, A., Al-Dabet, M. M., Ghosh, S., Kohli, S., Manoharan, J., ElWakiel, A., Gadi, I., Bock, F., Nazir, S., Wang, H., Lindquist, J. A., Nawroth, P. P., Madhusudhan, T., Mertens, P. R., Shahzad, K., & Isermann, B. (2017). Farnesoid X Receptor Agonism Protects against Diabetic Tubulopathy: Potential Add-On Therapy for Diabetic Nephropathy. Journal of the American Society of Nephrology : JASN, 28(11), 3182–3189. https://doi.org/10.1681/ASN.2016101123

Lydia Kynast, K., Volk, N., Fleming, T., & Herpel, E. (2017). Diabetes-Associated Biobanking: More Topical Than Ever?. Exp Clin Endocrinol Diabetes, 125(9), 603–609. https://doi.org/10.1055/s-0042-123039

Zemva, J., Fink, C. A., Fleming, T. H., Schmidt, L., Loft, A., Herzig, S., Knieß, R. A., Mayer, M., Bukau, B., Nawroth, P. P., & Tyedmers, J. (2017). Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux. Redox biology13, 674–686. https://doi.org/10.1016/j.redox.2017.08.007

Madhusudhan, T., Wang, H., Ghosh, S., Dong, W., Kumar, V., Al-Dabet, M. M., Manoharan, J., Nazir, S., Elwakiel, A., Bock, F., Kohli, S., Marquardt, A., Sögüt, I., Shahzad, K., Müller, A. J., Esmon, C. T., Nawroth, P. P., Reiser, J., Chavakis, T., Ruf, W., … Isermann, B. (2017). Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function. Blood, 130(12), 1445–1455. https://doi.org/10.1182/blood-2017-02-767921

Niopek, K., Üstünel, B. E., Seitz, S., Sakurai, M., Zota, A., Mattijssen, F., Wang, X., Sijmonsma, T., Feuchter, Y., Gail, A. M., Leuchs, B., Niopek, D., Staufer, O., Brune, M., Sticht, C., Gretz, N., Müller-Decker, K., Hammes, H. P., Nawroth, P., Fleming, T., … Berriel Diaz, M. (2017). A Hepatic GAbp-AMPK Axis Links Inflammatory Signaling to Systemic Vascular Damage. Cell reports20(6), 1422–1434. https://doi.org/10.1016/j.celrep.2017.07.023

da Silva, A. R., Neves, J., Mleczko-Sanecka, K., Tandon, A., Sauer, S. W., Hentze, M. W., & Muckenthaler, M. U. (2017). Cellular citrate levels establish a regulatory link between energy metabolism and the hepatic iron hormone hepcidin. Journal of molecular medicine (Berlin, Germany)95(8), 851–860. https://doi.org/10.1007/s00109-017-1551-3

Muckenthaler, M. U., Rivella, S., Hentze, M. W., & Galy, B. (2017). A Red Carpet for Iron Metabolism. Cell168(3), 344–361. https://doi.org/10.1016/j.cell.2016.12.034

Ekim Üstünel, B., Friedrich, K., Maida, A., Wang, X., Krones-Herzig, A., Seibert, O., Sommerfeld, A., Jones, A., Sijmonsma, T. P., Sticht, C., Gretz, N., Fleming, T., Nawroth, P. P., Stremmel, W., Rose, A. J., Berriel-Diaz, M., Blüher, M., & Herzig, S. (2016). Control of diabetic hyperglycaemia and insulin resistance through TSC22D4. Nature communications7, 13267. https://doi.org/10.1038/ncomms13267

Sharma, K. R., Heckler, K., Stoll, S. J., Hillebrands, J. L., Kynast, K., Herpel, E., Porubsky, S., Elger, M., Hadaschik, B., Bieback, K., Hammes, H. P., Nawroth, P. P., & Kroll, J. (2016). ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions. Scientific reports6, 37172. https://doi.org/10.1038/srep37172

Sulaj, A., Zemva, J., Zech, U., Woehning, A., Brune, M., Rudofsky, G., Nawroth, P. P., Fleming, T., & von Bauer, R. (2016). The effect of lifestyle intervention in obesity on the soluble form of activated leukocyte cell adhesion molecule. BMC endocrine disorders16(1), 56. https://doi.org/10.1186/s12902-016-0138-2

Schmitt, S., Kynast, K., Schirmacher, P., & Herpel, E. (2016). Challenges for quality management in implementation, maintenance, and sustainability of research tissue biobanks. Virchows Archiv : an international journal of pathology468(1), 93–99. https://doi.org/10.1007/s00428-015-1825-5

Cheng, Y. S., Seibert, O., Klöting, N., Dietrich, A., Straßburger, K., Fernández-Veledo, S., Vendrell, J. J., Zorzano, A., Blüher, M., Herzig, S., Berriel Diaz, M., & Teleman, A. A. (2015). PPP2R5C Couples Hepatic Glucose and Lipid Homeostasis. PLoS genetics11(10), e1005561. https://doi.org/10.1371/journal.pgen.1005561

Senyilmaz, D., Virtue, S., Xu, X., Tan, C. Y., Griffin, J. L., Miller, A. K., Vidal-Puig, A., & Teleman, A. A. (2015). Regulation of mitochondrial morphology and function by stearoylation of TFR1. Nature525(7567), 124–128. https://doi.org/10.1038/nature14601

Jörgens, K., Stoll, S. J., Pohl, J., Fleming, T. H., Sticht, C., Nawroth, P. P., Hammes, H. P., & Kroll, J. (2015). High tissue glucose alters intersomitic blood vessels in zebrafish via methylglyoxal targeting the VEGF receptor signaling cascade. Diabetes64(1), 213–225. https://doi.org/10.2337/db14-0352

Altamura, S., Kessler, R., Gröne, H. J., Gretz, N., Hentze, M. W., Galy, B., & Muckenthaler, M. U. (2014). Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload. Cell metabolism20(2), 359–367. https://doi.org/10.1016/j.cmet.2014.07.007

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